Polisch dating de

Posted by / 06-Dec-2017 14:49

Polisch dating de

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Lastly we will study the regulation of epithelial barrier function, autophagy and other fundamental cell biology functions by proteolytic processes.The goal of our planned collaborative research centre is to define the molecular mechanisms regulating the proteolytic steps in signaling cascades and to understand the conceptional difference between proteolytic steps and other fast and reversible signaling events such as phosphorylation and methylation.Such an understanding will not only help us to define pathophysiologic situations mediated by cytokines and growth factors but also to define points of intervention for the development of novel therapeutic principles.Since cytokines, growth factors, apoptosis, cellular barrier function and autophagy have been implied in the development of numerous chronic inflammatory or neurodegenerative diseases, our hypothesis is that proteolysis is a crucial and decisive factor in the pathophysiology of infection, skin disorders, neurodegeneration, inflammation and cancer.A few examples should be mentioned, which support our view of proteolysis as an integral part of inter- and intracellular signaling pathways.

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The general aim of the collaborative research centre is to obtain a profound understanding of proteolytic processes in cellular regulation and signaling and define the involvement of such processes in human pathophysiology.